Klinefelter sendromu ilk tan›mlanan kromozom anomalisi olup temel olarak hipergonadotropik hipogonadizm ve önükoid vücut yap›s› ile karakterizedir. S›kl› ¤›. ‘de tarif edilen Klinefelter sendromu hipogonadiz ve infertilitenin en sık tek nedenidir. Paternal mayoz hataları Klinefelter sendromunun yarısını oluştururken . Key words: Antisocial personality disorder, Klinefelter’s syndrome. ÖZET. Antisosyal kişilik bozukluğu ile karşımıza çıkan 18 yaşında Klinefelter’s sendromu tanısı.
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Klinefelter Sendromu: klinefelter syndrome. – Free Online Library
Rogol AD, Tartaglia N. Klinefeltwr Endocrinol Oxf ;4: Johns Hopkins Med J ; As the number of X chromosomes increases, patients show more dysmorphic features.
A serum FSH level higher than normal range with very low levels of testosterone is an important sign for Klinefelter syndrome. For patients in pubertal period, early diagnosis and immediate initiation of treatment is important.
Paternal meiosis errors account for about one half of Klinefelter syndrome while remainder are mostly due to maternal meiosis errors. Arch Intern Med ; For this purpose, the sperm detected in testicular is isolated with the so-called testicular sperm extraction Klinefelted method and then spermatozoa gets ejaculated into the ovum with the so-called intracytoplasmic sperm injection ICSI. The definitive diagnosis is made by sendromi analysis of lymphocytes from peripheral blood.
It has been shown that testosterone treatment has no effect on gynecomastia Especially in patients with low levels of testosterone, testosterone klinsfelter should be performed. Especially, serum follicle stimulating hormone FSH level is observed to be higher than normal in varying degrees.
Hypogonadism was found to be the most important cause of bone mineral deficiency.
File:Klinefelter’s Syndrome XXY DNA.jpg
Studies have shown no significant difference in efficacy between injected preparations and these other types Testosterone replacement for the risk of osteoporosis should be started early and must be maintained in long term In patients with Klinefelter syndrome, due to psychosocial consequences caused by androgen deficiency; character disorders, personality disorders, and behavioral problems arise. The so-called Klinefelter clinical syndrome was first defined in by Harry Klinefelter and his colleagues by showing the elevated excretion of urine FSH on 9 male patients who had small testes, gynecomastia and no ability of spermatogenesis 1.
A website offering different kind klinfeelter services and context with a certain frame determined by “Turkiye Klinikleri” and it is accessible on-line on http: It is mostly depending on where the tissue with the extra X chromosome is.
Rec Prog Horm Res ; In fact, studies show that the size of the penis and testicular volume are ssndromu in children with Klinefelter syndrome than those of their peers and they are also taller Considerations for androgen therapy in children and adolescents with Klinefelter syndrome 47, XXY.
It has been shown that in these patients, some tissues have 47,XXX and some others have 46,XY chromosomes.
In fact, estrogen levels can be normal in most patients. Chromosomal analysis from skin fibroblasts or testicular biopsy specimens may show mosaic chromosomal structure. No relationship has been detected between the occurrence of gynecomastia and increase in estrogen.
Infants, whose fathers have Klinefelter syndrome, mostly have normal karyotype. In patients with Klinefelter syndrome, serum testosterone levels usually begin to rise with puberty.
File:Klinefelter’s Syndrome XXY – Wikimedia Commons
Int J Clin Pract ; In patients with normal levels of testosterone, no replacement therapy is necessary. During delivery, nothing specific could be observed in infants related with classic Klinefelter syndrome.
Marketing Sales-Project Department Phone: One of the most typical laboratory findings in patients is an increase in serum gonadotropin levels in puberty.