Non-homogenous leukoplakia is a lesion of non-uniform appearance. The color may be predominantly white or a. Homogeneous leukoplakias: the most common type, are uniformly white plaques – common in the buccal (cheek) mucosa and usually of low malignant potential. Oral leukoplakia (leuko=white, plakia=patch) is a white patch in the mouth that There are two main types: homogenous and non-homogenous leukoplakia.

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Histopathological features Histological appearance of oral leukoplakia varies between no dysplasia and carcinoma. Bartholin’s cyst Kraurosis vulvae Vestibular papillomatosis Vulvitis Vulvodynia.

It can be used for mass screening campaigns. This content does not have an English version.

It showed that these dimensions increased gradually with significant difference from normal mucosa, oral leukoplakia and the highest level in oral carcinoma Another very common cause of white patches in the mouth is frictional or irritational trauma leading to keratosis.

The cohort studies about oral leukoplakia are very rare, so it is difficult to appreciate its real malignant transformation rate due to various regional habits 6 Erythroleukoplakia also termed speckled leukoplakia, erythroleukoplasia or leukoerythroplasia is a non-homogenous lesion of mixed white keratotic and red atrophic color.

Retrieved 6 May Andrews’ Diseases of the Skin: In it was decided that the name of leukoplakia should be limited only to a clinical diagnosis defined by exclusion of other white lesions such as oral lichen planus, white sponge nevus, nicotine stomatitis, leukoedema etc 5.


OL often arises in cheek and alveolar mucosa Neville and Day, Orofacial soft tissues — Soft tissues around the mouth. The sensitivity and specificity of computerized brush biopsy and scalpel biopsy in diagnosing oral premalignant lesions: So, for the establishment of a correct diagnosis of OL, such lesions must be excluded Warnakulasuriya et al.

Your doctor may recommend regular follow-up visits to monitor changes to your mouth or ongoing therapy to prevent leukoplakia patches from returning.

With epidermal involvement Leukoplakla contact dermatitis atopic dermatitis seborrheic dermatitis leukoplamia dermatitis lichen simplex chronicus Darier’s disease glucagonoma syndrome langerhans cell histiocytosis lichen sclerosus pemphigus foliaceus Wiskott—Aldrich syndrome Zinc deficiency.

Evolution OL may persist unchanged, progress, regress, or disappear Napier and Speight, It is debated whether candida infection is a primary cause of leukoplakia with or without dysplasia, or a superimposed secondary infection that occurs after the development of the lesion.

A digital manual for the early diagnosis of oral neoplasia

The term “dysplasia” is generally employed in the sense of a disordered development Izumo, The association of PVL and presence of Human Papilloma Virus has been hommogeneous previously but wasn’t homogenrous by further studies so far For this estimated rate, the author- Stefano Homogeneois, in a meta-analysis including 23 primary studies from all over the world published in the period found no difference between geographical areas and between younger and older patients.

Another possible choice is an attitude of “wait and see” to keep oral leukoplakia under clinical and histological surveillance with frequent visits and biopsies without other treatment. Recommended recall intervals vary. Archived from the original on Other Eagle syndrome Hemifacial hypertrophy Facial hemiatrophy Oral manifestations of systemic disease.


Clinical manifestations and treatment of Epstein-Barr virus infection. International Journal of Dentistry.

Oral Leukoplakia – an Update

Epub Jan These medications can suppress the Epstein-Barr virus, the cause of hairy leukoplakia. Ki is a cell cycle associated protein, of which expression is associated with cell proliferation. A clinicopathologic study oral leukoplakias. Adenosquamous carcinoma Basaloid squamous carcinoma Mucosal melanoma Spindle cell carcinoma Squamous cell carcinoma Verrucous carcinoma Oral florid papillomatosis Oral melanosis Smoker’s melanosis Pemphigoid Benign mucous membrane Pemphigus Plasmoacanthoma Stomatitis Aphthous Denture-related Herpetic Smokeless tobacco keratosis Submucous fibrosis Ulceration Riga—Fede disease Verruca vulgaris Verruciform xanthoma White sponge nevus.

Malignant transformation in patients with potentially malignant oral mucosal disorders: Besides oral leukoplakia, actinic cheilitis, lichen planus, and erythroplakia are also considered potentially malignant conditions affecting the oral cavity.

But other authors also mention the buccal mucosa, gingiva, leuko;lakia alveola ridges The detection of p53 in oral dysplastic lesions prompted many investigators to suggest that its abnormalities may constitute an early event in carcinogenesis.