Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as additive to the UV filter avobenzone in cosmetic sunscreen formulations – Evaluation. DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE. Health Concerns of the Ingredient: Overall Hazard. Cancer. Developmental & reproductive toxicity. Opinion on diethylamino hydroxybenzoyl hexyl benzoate. 2. About the Scientific Committees. Three independent non-food Scientific.

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Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe inand is also marketed in the U. Further research is needed to better understand which ingredients are safe and which pose a realistic hydroxyvenzoyl to marine ecosystems, in particular: The chemical UV filter oxybenzone has been studied most intensively and the following effects have been described:. The following measures are recommended:.


Studying the effects of pharmaceutical and personal care products PPCP mixtures to provide a more realistic picture of ecological risks posed by the use of these products. Damage and deformation of coral larvae planulae. The following measures are recommended: Investigating UV filter toxicity in relation to predicted warming and ocean acidification conditions.

Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at nm [ 1 ]. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability [ 1 ]. Like other UV filters, diethylamino hydroxybenzoyl hexyl benzoate may be subject to photodegradation upon absorption of UV radiation, which results in the compound passing from a ground state to benzoatee a singlet or triplet heexyl state [ 1 ]. No case of overdose has been reported.

They are generally found at barely detectable levels of a few parts per trillion but much higher concentrations of over 1 part per million ppm have been reported in a few locations e. To date, experiments have largely been undertaken ex-situ and there are concerns that they may not properly reflect conditions on the reef, where pollutants could be rapidly dispersed and diluted.


Diethylamino hydroxybenzoyl hexyl benzoate was not shown to be mutagenic, clastogenic, or phototoxic in vitro [ 4 ]. Considering the many stresses already faced by reefs and current concerns about the toxicity of certain components of sunscreens to corals, a proactive and precautionary approach to dealing with this issue may be required.

Research to date has also concentrated mainly on the effects of sunscreens and individual chemicals at subcellular, cellular and individual organism level, with very few studies of wider impacts. Most experiments have also been of relatively short duration 12 or 24 hours. Induction of the lytic viral cycle in symbiotic zooxanthellae with latent infections. Based on the findings of hyrdoxybenzoyl rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum [ 4 ].

Further research is needed to better understand which ingredients are safe and which pose a realistic threat to marine ecosystems, in particular:. Investigating the effects of sunscreen pollutants at reef community and ecosystem level. Bleaching of coral fragments and coral cells from various species of hard coral. Diethylamino hydroxybenzoyl hexyl benzoate 0. In rat and porcine benzkate, the percutaneous absorption was 0. This effect is more pronounced at higher water temperatures.

In general, heyl of UV filters used in experimental work have been higher than likely to be encountered in the reef environment. Many of these components have also been found in marine biota including fish, molluscs and corals as well as in sediments.

Impacts of sunscreens on coral reefs. Damage to coral DNA and to their reproductive success. Reducing the amount of harmful sunscreen components that reach the reef environment is a high priority and will require the involvement of governments, reef managers, divers, snorkelers and swimmers, and the tourism and pharmaceutical industries.


A small number of studies have shown that sunscreen and certain individual components of sunscreen can have negative effects on corals and other marine organisms under certain circumstances.

Identifying those ingredients that are safe and those that pose a realistic threat to marine ecosystems. Diethylamino hydroxybenzoyl hexyl benzoate. On the reef, while UV bexyl may be at lower concentrations, they can accumulate in organisms and sediment and thus become persistent, with largely unknown consequences. Researching bdnzoate extent and significance of bio-concentration and bio-accumulation of organic UV filters as well as the consequences of long-term, chronic exposure to sunscreen pollutants.

Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure diethylamkno UV radiation on human skin [ 2 ]. The hysroxybenzoyl UV filter oxybenzone has been studied most intensively and the following effects have been described: In vitrotopical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation [ 3 ].

They also contain inactive ingredients such as anti-microbial preservatives, moisturisers and anti-oxidants.


Where sunscreen components have been detected, concentrations are very variable. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions [ 4 ].

Encouraging the manufacture of reef-friendly sunscreens.

Drug created on December 03,